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Sniffing sweat might put you in a better mood?

A small pheromone study made a big splash in the media this week, announcing that male sweat contains a chemical that causes arousal in females.

The media’s sensationalization of the study made me feel dubious about the science behind it. I thought to myself, here we go again – some shoddy research and a lot of hand waving… I was determined enough to get the story straight, that I paid my $15 to the Journal of Neuroscience to get my hands on the original data. And I’m glad I did because my suspicions were NOT confirmed.

Claire Wyart et al. at UC Berkeley designed this study well. They took great pains to control the variables, account for confounders, and provide the appropriate environment for the study. “All testing was performed in a temperature and humidity controlled, stainless-steel-coated, 5 x 8 foot room equipped with HEPA (high-efficiency particulate air) and carbon filtration.” Wyart’s team also made meticulous note of previous research on the subject. They also repeated the study just to make sure that their findings were reproduceable. A total of 48 women participated.

In this double blind, placebo-control study they found that exposure to one of the chemicals in male sweat, androstadienone (AND), produced increased cortisol levels, elevated mood, and increased sexual arousal (when combined with provocative videos) up to an hour after the AND was inhaled.

Now, instead of focusing on the enhanced sexual arousal observation (that triggered the media blitz), Wyart suggested an interesting twist: what if AND could be used as a therapy for those suffering from cortisol deficiency (Addison’s disease)? Current standard therapy requires cortisol replacement which may cause peptic ulcers, osteoporosis, weight gain, mood disorders, and other pathologies. But AND is a potential “natural” solution.

Of course, I’m somewhat skeptical of this alternative since Addison’s is generally caused by an autoimmune attack on the adrenal gland cells – and I’m not sure that stimulating what’s left of them (with AND) would result in enhanced cortisol production. Still, Wyart raises an interesting point: what if we could learn how to positively influence the endocrine system with scent stimulation? Could this be a new method of treatment for women with anxiety, depression, or low libido but with far fewer side effects than our current methods?

Well, it’s too early to tell, but I think Wyart’s on to something. As she notes in her research article, AND is only one of hundreds of chemicals found in human sweat, and it is unclear if it is the most potent chemical in the arousal arena. It will be interesting to see if AND is eventually added to perfumes, cosmetic products, and the like as a means of tricking the body into feeling happier, sexier, and more balanced. Science meets aromatherapy? What do you think?

This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.


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4 Responses to “Sniffing sweat might put you in a better mood?”

  1. clairon says:

    Thank you for your article. I ll keep you updated on the follow-up of this study,

    Claire Wyart

  2. ValJonesMD says:

    Thanks for posting, Dr. Wyart! Revolution Health will be very interested to see your follow up research… Olfactory therapy may become an exciting new avenue for many different therapeutic applications. And the side effect profile is fantastic.

  3. Anonymous says:

    Now what interesting name could be given to a “perfume” like that.

  4. vickiep says:

    Occupational Therapists have been using olfactory stimulation in within the context of sensory integration processing improvment for young children for years.

    Now that we are starting to have some specific location science targeting various age groups, the stimulation can be more specific rather than a ‘shotgun’ approach !!

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Richmond, VA – In an effort to simplify inpatient medical billing, one area hospitalist group has determined that “altered mental status” (ICD-9 780.97) is the most efficient code for use in any patient work up.

“When you enter a hospital, you’re bound to have some kind of mental status change,” said Dr. Fishbinder, co-partner of Area Hospitalists, PLLC. “Whether it’s confusion about where your room is located in relationship to the visitor’s parking structure, frustration with being woken up every hour or two to check your vital signs, or just plain old fatigue from being sick, you are not thinking as clearly as before you were admitted. And that’s all the justification we need to order anything from drug and toxin screens, to blood cultures, brain MRIs, tagged red blood cell nuclear scans, or cardiac Holter monitoring. There really is no limit to what we can pursue with our tests.”

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Nursing staff at Richmond Medical Hospital report that efforts to inform hospitalists about foul smelling urine have generally fallen on deaf ears. “I have tried to tell the hospitalists about cloudy or bloody urine that I see in patients who are undergoing extensive work ups for mental status changes,” reports nurse Sandy Anderson. “But they insist that ‘all urine smells bad’ and it’s really more of a red herring.”

Another nurse reports that delay in diagnosing urinary tract infections (while patients are scheduled for brain MRIs, nuclear scans, and biopsies) can lead to worsening symptoms which accelerate and expand testing. “Some of my patients are transferred to the ICU during the altered mental status work up,” states nurse Anita Misra. “The doctors seem to be very excited about the additional technology available to them in the intensive care setting. Between the central line placement, arterial blood gasses, and vast array of IV fluid and medication options, urosepsis is really an excellent entré into a whole new level of care.”

“As far as medicine-induced mental status changes are concerned,” added Dr. Fishbinder, “We’ve never seen a single case in the past 10 years. Today’s patients are incredibly resilient and can tolerate mixes of opioids, anti-depressants, anti-histamines, and benzodiazepines without any difficulty. We know this because most patients have been prescribed these cocktails and have been taking them for years.”

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“I thought my mom was acting strange ever since she started taking stronger pain medicine for her arthritis,” says Nelly Hurtong, the daughter of one of Dr. Fishbinder’s inpatients. “But now I see that there are deeper reasons for her ‘altered mental status’ thanks to the brain MRI that showed some mild generalized atrophy.”

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Dr. Fishbinder is in the process of creating a half-day seminar on ‘altered mental status in the inpatient setting,’ offering CME credits to physicians who enroll. Richmond Medical Hospital intends to sponsor Dr. Fishbinder’s course, and franchise it to other hospitals in the state, and ultimately nationally.

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