June 3rd, 2010 by Steve Novella, M.D. in Better Health Network, Opinion, Quackery Exposed, Research
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The development of drugs and other treatments for specific symptoms or conditions relies heavily on either serendipity (the chance finding of a beneficial effect) or on an understanding of underlying mechanisms.
In pain, for example, there are limited ways in which we can block pain signals –- such as activating opiate receptors, or inhibiting prostaglandins. There are only so many ways in which you can interact with these systems. The discovery of a novel mechanism of modulating pain is therefore most welcome, and has the potential of leading to entirely new treatments that may have a better side effect profile than existing treatments and also have an additive clinical effect.
A recent study by Nana Goldman et. al., published in Nature Neuroscience, adds to our understanding of pain relief by identifying the role of adenosine in reducing pain activity in the peripheral nervous system. The researchers, in a nice series of experiments, demonstrated that producing a local painful stimulus in mice causes the local release of ATP (adenosine triphosphate) that peaks at about 30 minutes. This correlates with a decreased pain response in the mice. Further, if drugs are given that prolong the effect of adenosine, the analgesic effect itself is prolonged. Read more »
*This blog post was originally published at Science-Based Medicine*
June 1st, 2010 by Toni Brayer, M.D. in Better Health Network, Health Tips, News, Opinion, Research
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People who’ve been diagnosed cancer can be heartened by the results of a study that will be presented June 5 at the upcoming American Society of Clinical Oncology annual meeting. The researchers found that the practice of yoga helped cancer survivors improve sleep quality and reduce fatigue.
The lead researcher, Dr. Karen Mustian, professor of Radiation Oncology and Community and Preventive Medicine at the University of Rochester in New York, followed 410 patients who had already completed treatment for cancer but who experienced sleep disturbance that required medication. Read more »
*This blog post was originally published at EverythingHealth*
May 20th, 2010 by Steve Novella, M.D. in Better Health Network, Health Policy, News, Opinion, Research
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Two recent acupuncture studies have received some media attention, both purporting to show positive effects. Both studies are also not clinical efficacy trials, so cannot be used to support any claims for efficacy for acupuncture –- although that is how they are often being presented in the media.
These and other studies show the dire need for more trained science journalists or science blogging –- they only make sense when put into a proper context. No media coverage I read bothered to do this. Read more »
*This blog post was originally published at Science-Based Medicine*
May 6th, 2010 by David H. Gorski, M.D., Ph.D. in Better Health Network, Health Policy, Opinion, Quackery Exposed, Research, True Stories
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[Recently] I participated in a panel discussion at the Northeast Conference of Science and Skepticism (NECSS) with John Snyder, Kimball Atwood, and Steve Novella, who also reported on the conference. What I mentioned to some of the attendees is that I had managed to combine NECSS with a yearly ritual that I seldom miss, namely the yearly meeting of the American Association for Cancer Research (AACR) meeting.
There are two huge cancer meetings every year — AACR and the annual meeting of the American Society for Clinical Oncology (ASCO). AACR is the meeting dedicated to basic and translational research. ASCO, as the word “clinical” in its name implies, is devoted mainly to clinical research.
Personally, being a translational researcher myself and a surgeon, I tend to prefer the AACR meeting over ASCO, not because ASCO isn’t valuable, but mainly because ASCO tends to be devoted mostly to medical oncology and chemotherapy, which are not what I do as a surgeon. Each meeting draws between 10,000 to 15,000 or even more clinicians and researchers dedicated to the eradication of cancer. Read more »
*This blog post was originally published at Science-Based Medicine*
April 22nd, 2010 by David H. Gorski, M.D., Ph.D. in Better Health Network, Opinion, Research
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On Michael Specter, author of Denialism: How Irrational Thinking Hinders Scientific Progress, Harms the Planet, and Threatens Our Lives, and the danger of science denial:
Given that more than half of the video is devoted to discussing vaccine denialism, supplements, and HIV/AIDS denialism, I think Specter’s talk is quite appropriate for this blog. Read more »
*This blog post was originally published at Science-Based Medicine*
