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Latest Posts

Could Glowing Cats Be The Key To Finding A Cure For HIV?

Photo courtesy of the Mayo Clinic Scientists have added a new species to the menagerie of animals that glow, after introducing jellyfish genes into cats that can now glow green.

Scientists report that they transferred genes from monkeys (and jellyfish) into cats in order to study feline immunodeficiency virus (FIV), the cat equivalent of HIV. In cats and in people, immunodeficiency viruses deplete infection-fighting T-cells. Key proteins called restriction factors that would normally defend against the viruses are ineffective. The research appears in the September issue of Nature Methods.

To research potential treatments, physicians, virologists, veterinarians and gene therapy researchers from the Mayo Clinic and in Japan sought to mimic the way evolution would generate protective protein versions, according to a Mayo Clinic press release. They inserted monkey versions of a gene into the cat genome using gamete-targeted lentiviral transgenesis. This is done by inserting genes into feline eggs before sperm fertilization.

The monkey restriction factor, TRIMCyp, blocks FIV by attacking and disabling the virus as it tries to invade a cell. In the lab, the transgenic cat lymphocytes resisted FIV replication. The scientists said that they can now test the potential of various restriction factors for Read more »

*This blog post was originally published at ACP Internist*

A New Form Of Blogger’s Block

bloggerblockTrying to get some early morning writing in… but having a hard time reaching the keyboard with both hands.

This is a new, feline form of blogger’s block! (I’m sure Kerri @sixuntilme knows what I’m talking about).

Happy weekend…

Dr. Val

Latest Interviews

IDEA Labs: Medical Students Take The Lead In Healthcare Innovation

It’s no secret that doctors are disappointed with the way that the U.S. healthcare system is evolving. Most feel helpless about improving their work conditions or solving technical problems in patient care. Fortunately one young medical student was undeterred by the mountain of disappointment carried by his senior clinician mentors…

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How To Be A Successful Patient: Young Doctors Offer Some Advice

I am proud to be a part of the American Resident Project an initiative that promotes the writing of medical students residents and new physicians as they explore ideas for transforming American health care delivery. I recently had the opportunity to interview three of the writing fellows about how to…

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Latest Book Reviews

Book Review: Is Empathy Learned By Faking It Till It’s Real?

I m often asked to do book reviews on my blog and I rarely agree to them. This is because it takes me a long time to read a book and then if I don t enjoy it I figure the author would rather me remain silent than publish my…

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The Spirit Of The Place: Samuel Shem’s New Book May Depress You

When I was in medical school I read Samuel Shem s House Of God as a right of passage. At the time I found it to be a cynical yet eerily accurate portrayal of the underbelly of academic medicine. I gained comfort from its gallows humor and it made me…

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Eat To Save Your Life: Another Half-True Diet Book

I am hesitant to review diet books because they are so often a tangled mess of fact and fiction. Teasing out their truth from falsehood is about as exhausting as delousing a long-haired elementary school student. However after being approached by the authors’ PR agency with the promise of a…

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