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Liquid Material May Someday Be Used To Restore Damaged Soft Tissue

Yesterday, I came across this press release from Johns Hopkins regarding a new composite material which may someday be used to restore damaged soft tissue.  (photo credit)

The liquid material is a composite of biological and synthetic molecules which is injected under the skin.  Transdermal light is then used to “set” the material into a more solid structure.

The results of the early experiments in rats and humans has been reported in the July 27 issue of Science Translational Medicine (full reference below).

It is hoped that the new liquid material is a biosynthetic soft tissue replacement composed of poly(ethylene glycol) (PEG) and hyaluronic acid (HA).

From the press release Read more »

*This blog post was originally published at Suture for a Living*

Inside A Haitian Medical Clinic

Dr. Jon LaPook visits one of Haiti’s medical clinics nearly three months after the country’s devastating earthquake:

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Small Miracles In Haiti

Seven days ago, at a mission in the north of Haiti, I watched a nurse remove oxygen from a premature baby boy in order to give it to a woman in labor. The heartbeat of the baby who was about to be delivered had dropped dangerously low and there was only one working oxygen machine.

Perhaps the cord was wrapped around the baby’s neck or there was some other problem. A Caesarian section — which can quickly and safely deliver a baby who is in trouble — was not an option. The public hospital was at least an hour’s drive away over bumpy roads.

These kinds of cruel triage decisions are commonplace in Haiti and existed long before the earthquake struck on January 12th. The poorest country in the Western Hemisphere has never had an effective public health system. Thousands of non-governmental organizations (NGOs) — by some counts more than 10,000 — are trying to plug holes in the ship. What’s really needed is a new ship. Read more »

Nipple Sparing & Transplantation After Breast Surgery

Two nice articles in the June edition of the Journal of Plastic and Reconstructive Surgery.   Full references are given for both below.

There are many techniques used for nipple reconstruction which should tell you that none is perfect.  One of the main issues is loss of nipple projection over time.  So if it is safe to spare the nipple when doing a mastectomy so no nipple reconstruction is needed – perfect!

The first article below looks at when it can be safely spared in prophylactic mastectomy (risk-reduction mastectomy) and therapeutic mastectomy clinical scenarios.   Spear and colleagues did a literature review and came to the following conclusion:

It is clear from a review of the literature of the past 15 years that the subject of nipple-sparing mastectomy is complex and evolving. The subject is properly divided into two parts: risk prevention and therapeutic mastectomy.

There now seems little doubt that nipple-sparing mastectomy is an oncologically safe approach to prophylactic mastectomy. For that purpose, proper patient selection and technique remain open questions. ……….

Nipple-sparing mastectomy at the time of therapeutic mastectomy remains more controversial.  There is developing consensus by those interested in nipple-sparing mastectomy as a possibility with therapeutic mastectomy that it is best suited for women who meet certain criteria. …….

The collective data suggest that, using the above below criteria, the risk of occult tumor in the nipple should be 5 to 15 percent; that frozen section of the base of the nipple will identify many if not most of those occult tumors; and that the risk of occult tumor still being present in patients screened as above with frozen section-negative findings is as low as 4 percent.

The tumor criteria listed include:

  • The tumor should be 3 cm in diameter or less
  • The tumor should be 2 cm away from center of the nipple
  • Clinically negative axillae or sentinel node negative
  • No skin involvement, and no inflammatory breast cancer.
  • If possible, they should undergo preoperative magnetic resonance imaging of the breast to further exclude nipple involvement.

When the nipple can be spared then there is no need for nipple reconstruction.  When it can’t be, then the nipple sharing technique can be useful.  As with the above, the cancer risk is addressed:

Fears of cancer in the transplanted nipple and concerns for surveillance are thus far unfounded. This occurrence has never been described in the literature. Furthermore, as more liberal use of nipple-sparing mastectomy occurs, a large cohort of patients with retained nipples will be able to be followed over time to see whether we even need to be concerned. For now, simple self-examination as performed by these patients is appropriate.

The article gives a good description of two different ways to perform the nipple sharing depending on the shape of the donor nipple.

Both articles are worth your time to read.


Nipple-Sparing Mastectomy; Plast & Recontr Surg 123(6):1665-1673, June 2009; Spear, Scott L.; Hannan, Catherine M.; Willey, Shawna C.; Cocilovo, Costanza

Unilateral Nipple Reconstruction with Nipple Sharing: Time for a Second Look; Plast & Reconstr Surg 123(6):1648-1653, June 2009; Zenn, Michael R.; Garofalo, Jo Ann

Related Posts

Breast Reconstruction – Part I

Breast Reconstruction – Part II

Integrating Radiation Therapy & Breast Reconstruction

*This blog post was originally published at Suture for a Living*

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