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Insect-Killing Fungus May Provide Basis For New Multiple Sclerosis Treatment

A very well-written review of an orally-active drug for multiple sclerosis has just appeared in the April 25th issue of the Journal of Natural Products, a joint publication of the American Chemical Society and the American Society of Pharmacognosy.

The review, Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite, is co-authored by Cherilyn R. Strader, Cedric J. Pearce, and Nicholas H. Oberlies. In the interest of full disclosure, the latter two gentlemen are research collaborators of mine from Mycosynthetix, Inc. (Hillsborough, NC) and the University of North Carolina at Greensboro. My esteemed colleague and senior author, Dr. Oberlies, modestly deflected my request to blog about the publication of this review.

So, I am instead writing this post to promote the excellent work of his student and first author, Cherilyn Strader. As of [Wednesday] morning, this review article is first on the list of most-read articles in the Journal. This status is noteworthy because the review has moved ahead of even the famed David Newman and Gordon Cragg review of natural product-sourced drugs of the last 25 years, the JNP equivalent of Pink Floyd’s The Dark Side of the Moon (the album known for its record 14-year stay on the Billboard music charts.). Read more »

*This blog post was originally published at Science-Based Medicine*

The Selectiveness Of Science Denialism

Statement #1:

The holocaust never happened. Hitler loved Jews and respected Jewish culture. The photographic evidence of the camps, including the bodies and atrocities, were all fakes designed by the State of Israel to generate international sympathy.

Statement #2:

Traditional Chinese medicine (TCM) is an effective treatment for numerous medical conditions. Acupuncture has been around for centuries and is widely practiced in China and elsewhere. Science has proven its efficacy in controlled experiments.

With any luck, that first statement should generate dozens of hits from watchdog groups berating me for spreading the vile lie of Holocaust denial.

The second statement, or words perilously close to that effect, has appeared in the New England Journal of Medicine, a previously-prestigious medical publication now revealed to be no better than the National Enquirer or any other sleazy tabloid, fit only for lining bird cages and wrapping week-old fish. Thanks to this wonderful article by Harriet Hall, it turns out that the first reference to “needling” in Chinese medical literature is from 90 B.C., although it doesn’t refer to acupuncture. It’s talking about lancing abscesses and bloodletting. The technology required to make sufficiently thin needles didn’t even exist until 400 years ago.The Chinese government tried to ban acupuncture several times around the turn of the twentieth century. The actual term “Traditional Chinese Medicine” was coined by Mao Tse Dung in the 1960s! (Go read Hall’s article linked above. It’s awesome.)

So riddle me this, campers: Why (and how) do science denialists get away with these outrageous lies? Read more »

*This blog post was originally published at Musings of a Dinosaur*

Latest Interviews

IDEA Labs: Medical Students Take The Lead In Healthcare Innovation

It’s no secret that doctors are disappointed with the way that the U.S. healthcare system is evolving. Most feel helpless about improving their work conditions or solving technical problems in patient care. Fortunately one young medical student was undeterred by the mountain of disappointment carried by his senior clinician mentors…

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How To Be A Successful Patient: Young Doctors Offer Some Advice

I am proud to be a part of the American Resident Project an initiative that promotes the writing of medical students residents and new physicians as they explore ideas for transforming American health care delivery. I recently had the opportunity to interview three of the writing fellows about how to…

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Latest Book Reviews

Book Review: Is Empathy Learned By Faking It Till It’s Real?

I m often asked to do book reviews on my blog and I rarely agree to them. This is because it takes me a long time to read a book and then if I don t enjoy it I figure the author would rather me remain silent than publish my…

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The Spirit Of The Place: Samuel Shem’s New Book May Depress You

When I was in medical school I read Samuel Shem s House Of God as a right of passage. At the time I found it to be a cynical yet eerily accurate portrayal of the underbelly of academic medicine. I gained comfort from its gallows humor and it made me…

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Eat To Save Your Life: Another Half-True Diet Book

I am hesitant to review diet books because they are so often a tangled mess of fact and fiction. Teasing out their truth from falsehood is about as exhausting as delousing a long-haired elementary school student. However after being approached by the authors’ PR agency with the promise of a…

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