A new contrast agent based on maltodextrin has been developed at Georgia Tech that can provide in vivo imaging of bacteria with a sensitivity two orders of magnitude greater than previously achieved.
Unlike most previous methods, the new probes are able to enter bacterial cells by pretending to be food, while avoiding being ingested by the mammalian cells.
From Georgia Tech:
Maltodextrin-based imaging probes consist of a fluorescent dye linked to maltohexaose, which is a major source of glucose for bacteria. The probes deliver the contrast agent into bacteria through the organism’s maltodextrin transporter, which only exists in bacterial cells and not mammalian cells.
In experiments using a rat model, the researchers found that Read more »
*This blog post was originally published at Medgadget*