Better Health: Smart Health Commentary Better Health (TM): smart health commentary

Article Comments

New Theories About A Link Between Uterine Environment And Autism Raise Questions Without Answers

Two news events got people talking recently.  One was that Casey was deemed not guilty of killing little daughter Caylee ( “O.J. all over again”, I heard repeatedly).  I must admit I was rather surprised….

The second was the results of two new studies that were published in the Archives of General Psychiatry.  One of them stated that environmental factors during pregnancy might contribute as much as genetics in the development of autism spectrum disorders.  The 2nd study conducted by Kaiser Permanente Northern California found a 3 times higher risk of autism if the mother took antidepressants in the first trimester of pregnancy.

With the incidence of autism disorders increasing over time to the current range of 3-6 per 1,000 births, these studies are of interest to millions of parents and professionals.  Autism affects boys at a rate of three times more than girls,  and is usually detected by the age of 3.   The cause has been maddeningly unknown.

While genes certainly play a part (as they do in most every disorder) other theories and assertions have been disproven.  It certainly does not have anything to do with “poor mothering” or “lack of maternal bonding”.  Those theories did more harm than bloodletting in the 19th century!  The link between autism and vaccines has been thoroughly debunked.  If you believe in science and research, you must believe that vaccines are not the cause and finally leave that one in the dust.

This new study looked at 192 pairs of identical and fraternal twins.  One of the twins in each pair had classic autism.  Some of the other twin sibs also had classic autism or Asperger’s syndrome, a mild disorder in the autism spectrum.

(sidebar:  Rent “Temple Grandin”, a great movie that shows a super high functioning autistic woman who changed the world of animal husbandry)

The study found that autism spectrum disorders occurred in both twins in 77% of the male identical twins and in 50% of the female identical twins.  Since identical twins share the exact same DNA and genes, you would expect a 100% autism rate in identical twins.  The rate was even lower in fraternal twins. (who are like any other brother and sister sibling).  The rates of autism in non-twin brothers and sisters is even lower still, suggesting conditions that the twins shared in the womb played a role in developing autism.

The second study found an elevated risk of autism in children whose mother took SSRI antidepressants (Prozac, Zoloft, Celexa, Lexapro) during the year before delivery.  Although the risk was low (2.3%), if a pregnant mom took antidepressants during the first trimester, the risk of autism was 3X higher than mothers who didn’t take SSRIs.

So what does all of this mean?  The studies do not tell us what intra-uterine factors might play a role in autism.  It could be diet, infection, stress, differences in blood flow. It could be a number of different factors that just happen to come together at a certain developmental time.  We just don’t know.  Presumably the uterine environment is the same for both twins and the mom is the same but we know twins do not develop exactly the same.

Scientific breakthroughs usually happen when a study helps us ask even more questions.  These new studies give us clues and raise more questions.

As for Casey Anthony, she will have to live in her own hell.

*This blog post was originally published at EverythingHealth*

You may also like these posts

    None Found

Read comments »

Comments are closed.

Return to article »

Latest Interviews

IDEA Labs: Medical Students Take The Lead In Healthcare Innovation

It’s no secret that doctors are disappointed with the way that the U.S. healthcare system is evolving. Most feel helpless about improving their work conditions or solving technical problems in patient care. Fortunately one young medical student was undeterred by the mountain of disappointment carried by his senior clinician mentors…

Read more »

How To Be A Successful Patient: Young Doctors Offer Some Advice

I am proud to be a part of the American Resident Project an initiative that promotes the writing of medical students residents and new physicians as they explore ideas for transforming American health care delivery. I recently had the opportunity to interview three of the writing fellows about how to…

Read more »

See all interviews »

Latest Cartoon

See all cartoons »

Latest Book Reviews

Book Review: Is Empathy Learned By Faking It Till It’s Real?

I m often asked to do book reviews on my blog and I rarely agree to them. This is because it takes me a long time to read a book and then if I don t enjoy it I figure the author would rather me remain silent than publish my…

Read more »

The Spirit Of The Place: Samuel Shem’s New Book May Depress You

When I was in medical school I read Samuel Shem s House Of God as a right of passage. At the time I found it to be a cynical yet eerily accurate portrayal of the underbelly of academic medicine. I gained comfort from its gallows humor and it made me…

Read more »

Eat To Save Your Life: Another Half-True Diet Book

I am hesitant to review diet books because they are so often a tangled mess of fact and fiction. Teasing out their truth from falsehood is about as exhausting as delousing a long-haired elementary school student. However after being approached by the authors’ PR agency with the promise of a…

Read more »

See all book reviews »

Commented - Most Popular Articles