October 3rd, 2011 by RyanDuBosar in Research
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Dermatologists spend their days telling patients to avoid the sun and their careers striving to practice in it. They’re leaving the Midwest and mountain states to practice in the southern and western U.S.
To evaluate the migration patterns of dermatologists from residency to clinical practice, researchers reviewed data from the American Academy of Dermatology’s membership database. They looked at 7,067 dermatology residents who completed training before 2005 and were actively practicing in 2009. Results appeared at the September issue of the Archives of Dermatology.
Most graduates from Middle Atlantic and Pacific census divisions relocated Read more »
*This blog post was originally published at ACP Internist*
September 30th, 2011 by RyanDuBosar in Research
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Married men who have no children have a 17% higher risk of dying from cardiovascular disease after the age of 50 than men with two or more children. But whether that’s because of a physical cause, a sociological effect or self-selection (sick people may choose not to have kids) isn’t known.
To determine if the number of kids predicts cardiovascular death, researchers used data from the NIH-AARP Diet and Health Study of nearly 135,000 men ages 50 to 71 without prior cardiovascular disease who were followed-up for an average of 10 years. That study mailed 3.5 million questionnaires from 1995 through 1996 to AARP members living in California, Florida, Pennsylvania, New Jersey, North Carolina, and Louisiana or in Atlanta or Detroit. Nearly 586,000 people returned the questionnaire, which underwent follow-up surveys in 1996-1997 and 2004-2006. Results appeared online Sept. 26 in the journal Human reproduction.
Almost all (92%) men had Read more »
*This blog post was originally published at ACP Internist*
September 27th, 2011 by RyanDuBosar in Research
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Intranasal insulin stabilized or improved cognition and function and preserved cerebral metabolic rate of glucose in brain regions affected by Alzheimer’s disease, concluded researchers from a phase II trial. But more and larger trials are needed before any conclusions can be drawn, they also cautioned.
Insulin is important to normal brain function, and reduced insulin levels may contribute to Alzheimer’s disease, researchers noted. To examine the effects of intranasal insulin in adults with amnestic mild cognitive impairment or Alzheimer’s disease, researchers conducted a randomized, double-blind, placebo-controlled trial in a VA medical center.
The intent-to-treat sample consisted of 104 adults with amnestic mild cognitive impairment (n=64) or mild to moderate Alzheimer’s disease (n=40) defined as Clinical Dementia Rating scores of 0.5-1 and Mini-Mental State Examination scores greater than 15.
Participants received Read more »
*This blog post was originally published at ACP Internist*
September 25th, 2011 by RyanDuBosar in Research
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More than two in five patients hesitate to discuss depression in the primary care setting, leading researchers to offer practical tips on how to encourage people to broach the subject.
The big reasons for not talking to doctors included fears about patient confidentiality and fear of losing emotional control in front of the doctor, among those with a history of depression. Among those with no prior history, a fear of antidepressants/psychiatry and the perception that primary care isn’t the right setting are two big reasons.
To learn why patients choose not to talk about their depression, researchers Read more »
*This blog post was originally published at ACP Internist*
September 20th, 2011 by RyanDuBosar in Research
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Scientists have added a new species to the menagerie of animals that glow, after introducing jellyfish genes into cats that can now glow green.
Scientists report that they transferred genes from monkeys (and jellyfish) into cats in order to study feline immunodeficiency virus (FIV), the cat equivalent of HIV. In cats and in people, immunodeficiency viruses deplete infection-fighting T-cells. Key proteins called restriction factors that would normally defend against the viruses are ineffective. The research appears in the September issue of Nature Methods.
To research potential treatments, physicians, virologists, veterinarians and gene therapy researchers from the Mayo Clinic and in Japan sought to mimic the way evolution would generate protective protein versions, according to a Mayo Clinic press release. They inserted monkey versions of a gene into the cat genome using gamete-targeted lentiviral transgenesis. This is done by inserting genes into feline eggs before sperm fertilization.
The monkey restriction factor, TRIMCyp, blocks FIV by attacking and disabling the virus as it tries to invade a cell. In the lab, the transgenic cat lymphocytes resisted FIV replication. The scientists said that they can now test the potential of various restriction factors for Read more »
*This blog post was originally published at ACP Internist*
