August 25th, 2011 by Toni Brayer, M.D. in News, Research
Tags: Anti-Aging Drugs, Designer Drug, Diet, Diet Drugs, Eating Habits, Fat, Healthy, Insulin Sensitivity, Liver, Longevity, Low-calorie diets, Metabolism, Mice, Obese, Obesity Epidemic, Research, Resveratrol, sirtuins, SRT-1720
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I usually choose not to write about the “new new scientific thing” that gets picked up by the press, because early research is usually not reproducible and good science takes a long time to validate as true. But since we know that mice and rats that are kept on low-calorie diets live 30% longer (and healthier) than their fat cohorts, I was interested in a new research compound, SRT-1720, that was shown to protect obese mice from diseases of obesity. Fat mice lived 44% longer if they were given this drug.
The “designer” drug works by Read more »
*This blog post was originally published at EverythingHealth*
August 25th, 2011 by Shadowfax in Research, True Stories
Tags: Abdominal Pain, Children, CT Scan, ED Visits, Emergency Department, ER, Optimum Rate of CT, Peak Utilization, Pediatrics, Radiation Exposure, Radiation-minimizing technique, Trauma Center
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Well, this is satisfying. Over the years, in our ER we have mirrored the nationwide trend and have significantly increased the utilization of CT scans across the board. The reasons are manifold. Some cite malpractice risks, and indeed in our large group we have had one lawsuit for a pediatric head injury and another for a missed appendicitis which probably did contribute. But, in my opinion, there have been many other drivers of the increased use. For one, CTs have gotten way, way better over the last 15 years, which quite simply has made them a better diagnostic tool. They’ve also gotten way faster. As the facilities have invested in CT scanners, they have increased their capacity and increased their staffing, so the barriers to their use have rapidly diminished. I am so old that I remember when ordering a CT involved calling a radiologist and getting their approval! No more of that, I can tell you.
But a couple of years ago, we really started paying attention (perhaps belatedly) to Read more »
*This blog post was originally published at Movin' Meat*
August 24th, 2011 by Paul Auerbach, M.D. in News, Research
Tags: Allergic Reaction, Copperhead, Cottonmouth, CroFab, Crotalidae polyvalent, Eric Lavonas, Fab Antivenom, FabAV, Hypersensitivity, Rattle Snake, Severe Crotaline Snakebite, Viper Snake
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The current standard of care with regard to using antivenom for pit viper snakes (e.g., rattlesnakes, copperheads, cottonmouths) in North America is to use Crotalidae polyvalent immune Fab antivenom (CroFab;FabAV). This antivenom is created using a process that obtains antibodies “raised” by immunizing sheep and then harvesting and purifying the product. One of the major benefits of using this product is to take advantage of a lesser incidence of allergic reactions (than have traditionally been observed with previous products). It appears that the situation regarding the incidence of allergic reactions may be better than previously thought.
In the article, “Short Term Outcomes After Fab Antivenom Therapy for Severe Crotaline Snakebite,” Eric Lavonas, MD and colleagues (Ann Emerg Med 2011;57:128-137) examined Read more »
This post, Fab Antivenom Found To Cause Fewer Allergic Reactions Than Previously Thought, was originally published on
Healthine.com by Paul Auerbach, M.D..
August 24th, 2011 by admin in Health Tips, Research
Tags: Cancer, CDC, Cigarette Smoking, Diabetes, Disease, Environment, Environmental Factors, Gene-Environment Interactions, Genetics, Genomics, Healthy Diet, Heart Disease, Nature Vs. Nurture, Preventive Measures, Psychiatry, Risk Factors, Sedentary Lifestyle
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A recent article in the Archives of General Psychiatry by Hallmayer et al. discussed the role of genetic and environmental factors in autism and autism spectrum disorders (ASD). The study was a heritability analysis of 192 pairs of twins, which attributed 37 percent of the variation in risk of autism to genetic factors and 55 percent to shared environmental factors. The authors contrasted their findings with those of previous studies, which had given genetics a much higher share (up to 90%).
Rather than contradicting previous research, the new results provide more evidence that autism, like many other common diseases, results from both genetic and environmental factors. The way that these elements – often called “nature and nurture” – influence health outcomes has been discussed for decades but is often misunderstood, even among scientists.
Disease Causation is Not as Easy as… Pie Read more »
*This blog post was originally published at Genomics and Health Impact Blog*
August 23rd, 2011 by Elaine Schattner, M.D. in Opinion, Research
Tags: Academic Medicine, Alternative Medicine, Cancer Treatment, Communication, Disclosure, Dr. Andrew Lowy, Grey's Anatomy, Hipec, Hot Chemotherapy, hyperthermic intraperitoneal chemotherapy, Informed Consent, Medical News, New York Times, USC San Diego
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There’s so much weird and exciting cancer news this week, it’s hard to keep up!
Double-kudos to Andrew Pollack on his front-page and careful coverage in the New York Times of the hyperthermic intraperitoneal chemotherapy (Hipec) technique that’s being used at some name-brand health care facilities to treat colon cancer.
First, he spares no detail in the Times describing the seemingly primitive, crude method:
….For hours on a recent morning at the University of California, San Diego, Dr. Andrew Lowy painstakingly performed the therapy on a patient.
After slicing the man’s belly wide open, Read more »
*This blog post was originally published at Medical Lessons*
I usually choose not to write about the “new new scientific thing” that gets picked up by the press, because early research is usually not reproducible and good science takes a long time to validate as true. But since we know that mice and rats that are kept on low-calorie diets live 30% longer (and healthier) than their fat cohorts, I was interested in a new research compound, SRT-1720, that was shown to protect obese mice from diseases of obesity. Fat mice lived 44% longer if they were given this drug.
