May 18th, 2011 by Jeffrey Benabio, M.D. in Health Tips
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“I hate needles.” Patients say this to me everyday. When you think about it, who “likes” needles?
Skin biopsies are relatively painless, but they still involve the dreaded needle and always leave scars. The trouble is we dermatologists cannot guarantee that a mole isn’t skin cancer without sending a biopsy for pathology. That is, until now.
Although it is not available in clinic yet, an almost incredible new innovation might allow us to determine if a mole is cancerous by testing the DNA of the mole. It sounds like it’s from an episode of CSI, but it’s real.
Melanomas have DNA (messager-RNA to be exact, but it’s a little complicated) that differentiate them from normal moles, so testing the mole for melanoma requires only a tiny sample of skin. Fortunately, no needles are needed — in fact, no sharp objects are necessary at all. Read more »
*This blog post was originally published at The Dermatology Blog*
March 26th, 2011 by Berci in Research
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It’s a pleasure to share the great news that we just published our review in Trends in Molecular Medicine under the title, Gene expression profiles in peripheral blood for the diagnosis of autoimmune diseases. We looked at the literature and wrote about whether peripheral blood can be used for the diagnosis of autoimmune diseases or the prediction of the effectiveness of therapies. We also came up with a decision tree and a set of proposed guides in order to facilitate inter-disciplinary collaborations.
The paper is not publicly available, but if you are interested, I’d be happy to send it to you via e-mail.
Gene expression profiling in clinical genomics has yet to deliver robust and reliable approaches for developing diagnostics and contributing to personalized medicine. Owing to technological developments and the recent accumulation of expression profiles, it is a timely and relevant question whether peripheral blood gene expression profiling can be used routinely in clinical decision making. Here, we review the available gene expression profiling data of peripheral blood in autoimmune and chronic inflammatory diseases and suggest that peripheral blood mononuclear cells are suitable for descriptive and comparative gene expression analyses. A gene-disease interaction network in chronic inflammatory diseases, a general protocol for future studies and a decision tree for researchers are presented to facilitate standardization and adoption of this approach.
*This blog post was originally published at ScienceRoll*
January 28th, 2011 by Berci in Quackery Exposed, Research
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Luc Montagnier received the 2008 Nobel Prize for his discovery of the human immunodeficiency virus (HIV), but now he’s come up with a more-than-strange theory. He thinks DNA can teleport from one tube to another via electromagnetic signals. Is this the so-called “Nobel disease?”
French virologist Luc Montagnier stunned his colleagues at a prestigious international conference when he presented a new method for detecting viral infections that bore close parallels to the basic tenets of homeopathy.
Although fellow Nobel prize winners — who view homeopathy as quackery — were left openly shaking their heads, Montagnier’s comments were rapidly embraced by homeopaths eager for greater credibility.
Montagnier told the conference last week that solutions containing the DNA of pathogenic bacteria and viruses, including HIV, “could emit low frequency radio waves” that induced surrounding water molecules to become arranged into “nanostructures.” These water molecules, he said, could also emit radio waves.
He suggested water could retain such properties even after the original solutions were massively diluted, to the point where the original DNA had effectively vanished. In this way, he suggested, water could retain the “memory” of substances with which it had been in contact — and doctors could use the emissions to detect disease.
*This blog post was originally published at ScienceRoll*
October 14th, 2010 by Berci in Better Health Network, Medical Art, Research
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A few months ago, Alexandra Pajak, a graduate student at the University of Georgia, contacted me about an album of music based on the DNA of the HIV virus she was about to release. I feel lucky that the album is just on its way to my CD player right now.
You can buy the album on Amazon (release date is October 26.) Note that some of the proceeds will go to the Emory Vaccine Center, which conducts research for an HIV vaccine. If you wonder how it was made, here’s the explanation:
Sounds of HIV is a musical translation of the genetic code of HIV, the human immunodeficiency virus. Every segment of the virus is assigned music pitches that correspond to the segment’s scientific properties. In this way, the sounds reflect the true nature of the virus. When listening from beginning to end, the listener hears the entire genome of HIV.
In English, the nucleotides Adenine, Cytosine, Uracil/Thymine, and Guanine are abbreviated with the letters A, C, T, and G. Since A, C, and G are also musical pitches in the Western melodic scale, these pitches were assigned to the matching nucleotides. To form two perfect fifths (C-G and D-A), “D” was arbitrarily assigned to musically represent Uracil. I assigned the pitches of the A minor scale to the amino acids based on their level of attraction to water.
On Sounds of HIV, depending on the track, only nucleotides and/or amino acids “play” as music. Tracks 1 and 10 are based on the first and last nucleotides of the RNA chain. Tracks 2-9 “play” the proteins and sometimes the nucleotides on top of the proteins.
*This blog post was originally published at ScienceRoll*
September 16th, 2010 by Mark Crislip, M.D. in Better Health Network, Opinion, Research
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Humans love to find patterns in the world. Sometimes patterns exist, sometimes they are imaginary. Sometimes you can see a pattern that may be interesting and ignore its significance. As a resident I used to say that anyone who smokes three packs of cigarettes a day has to be schizophrenic. It was meant more as a joke when, in fact, it was later discovered that tobacco helps ameliorate the symptoms of schizophrenia. I need to pay more attention.
Part of my job is to look for patterns as a key to the patients diagnosis. Diseases and pathogens tend to (more or less) cause reproducible signs and symptoms and looking for that pattern is often the most helpful clue towards finding the diagnosis. Of course things are never as easy as one would like, as you have to consider whether you are seeing common manifestations of a common disease, uncommon manifestations of a common disease, common manifestations of a uncommon disease and, the hardest, uncommon manifestations of an uncommon disease. When I have a complex or uncertain cause, I explicitly run through that, and other, litanies so I do not miss a unusual diagnosis.
Chronic fatigue syndrome (CFS) has, at least to my way of thinking, two patterns. I see the occasional CFS patient in clinic and, I hope, pay attention to their disease patterns. I keep in mind I may be seeing a pattern that does not exist, but looking for disease patterns is what doctors are trained to do. Read more »
*This blog post was originally published at Science-Based Medicine*
