November 27th, 2011 by Medgadget in Research
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Embryonic stem cells have the potential to treat a range of diseases and conditions for which current treatment options are lacking. Capable of differentiating practically into all of the types of tissues in the human body, the cells could be used in therapies to treat conditions such as paralysis, brain damage, and Parkinson’s disease. Among the many challenges to be overcome before human embryonic stem cells live up to their promise is difficulty in proving whether transplanted stem cells can integrate successfully in vivo.
Researchers from University of Wisconsin-Madison have announced progress on that front. Having created Read more »
*This blog post was originally published at Medgadget*
August 21st, 2011 by Medgadget in Research
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A technique to identify myelination in order to map the layout of cortical areas in the human brain has been developed by researchers led by David van Essen at the Washington University School of Medicine in St. Louis. It is generally known that myelination levels are different throughout the cerebral cortex. The best way to assess it is to investigate the brain post mortem. Using the new technique of myelination mapping, it will be possible to accurately map individual cortical areas in vivo. The researchers used their method on a group of control subjects and found an excellent agreement between the spatial gradients of the myelin maps and already published anatomical and functional information about cortical areas, mostly based on post-mortem histology.
Using data from T1 and T2-weighted MRIs, the team has been able to Read more »
*This blog post was originally published at Medgadget*
July 22nd, 2011 by Medgadget in Research
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A new contrast agent based on maltodextrin has been developed at Georgia Tech that can provide in vivo imaging of bacteria with a sensitivity two orders of magnitude greater than previously achieved.
Unlike most previous methods, the new probes are able to enter bacterial cells by pretending to be food, while avoiding being ingested by the mammalian cells.
From Georgia Tech:
Maltodextrin-based imaging probes consist of a fluorescent dye linked to maltohexaose, which is a major source of glucose for bacteria. The probes deliver the contrast agent into bacteria through the organism’s maltodextrin transporter, which only exists in bacterial cells and not mammalian cells.
In experiments using a rat model, the researchers found that Read more »
*This blog post was originally published at Medgadget*
March 30th, 2010 by Medgadget in Better Health Network, News, Research
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While gene therapy has always seemed just on the verge of being right around the corner, the limitation has always been delivery of the gene. How do you get the new gene to the right cells and activated?
An in-vivo mice study in the Proceedings of the National Academy of Sciences (PNAS) may take us closer to a usable delivery system. Rui Maeda-Mamiya of the University of Tokyo and others were able to get diabetic mice to increase their insulin levels after delivery of a insulin 2 gene by a water-soluble fullerene. Read more »
*This blog post was originally published at Medgadget*