February 21st, 2007 by Dr. Val Jones in News
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Malaria is caused by a crafty little parasite that has become resistant to many medicines. But now researchers at Northwestern University have discovered a chink in its armor – a blood pressure medicine called propranolol. Who knew that a common beta-blocker used to treat hypertension might provide the death blow to such a scourge?
Usually, malarial parasites infect their host’s blood stream through a mosquito bite, and then congregate in the liver and pounce on red blood cells as they pass by. They have a way of adhering to the red blood cells via certain surface receptors (beta 2 adrenergic receptors linked to Gs proteins). They latch on to the red cells and then burrow into the cell and hijack it in order to reproduce inside it. Then, like the horror movie Alien, once they’re fully grown (into “schizonts”) they burst out of the cells and roam free to repeat the process all over again.
Now propranolol happens to block the Gs proteins, which effectively makes it impossible for the parasites to attach themselves to the red blood cells (which they need to use to reproduce themselves).
So what’s the caveat to of all this? Well, folks don’t know they have been infected with malaria until they have symptoms, and the symptoms include high fevers and low blood pressure… so giving someone a medicine that lowers their blood pressure even further might not be a good idea.
The other caveat is that propranolol works like a charm in the test tube, and in mice, but we haven’t yet tried it out in humans who have malaria.
Still, it seems to me that a little bit of propranolol might go a long way to preventing malarial infections in at risk populations. I’ll be interested to see what further studies show!
And if you’re interested, I’ll create a few more blog posts about parasites and other creepy crawly human invaders… Just let me know if you can handle more of this!
This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
February 21st, 2007 by Dr. Val Jones in News
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I really couldn’t help but feel saddened by three recent news stories about the continued attitudes that are so harmful to women. If these media reports are right, Japan’s leadership appears to be way off target, referring to women as baby machines and refusing to apologize for enslaving and raping ~200K women in World War II.
America has a more insidious version of sexism that can harm young minds – exposing children repeatedly to age-inappropriate sexually explicit images and ideas. As we expand our understanding of neuronal plasticity, it is becoming more and more clear that what we see and experience can imprint itself on our brains and literally change the way we think and feel. We spend a lot of time worrying about what we put in our bodies (e.g. avoiding trans fats, food chemicals, etc.) I wonder if we should think a little bit more critically about what we let into our minds?
Here’s what I’m talking about:
Japanese health minister says women are “birth-giving machines”
In a report in which the health minister explained how dangerous the low birth rate is for Japan’s economic future, he suggested that women are a rate limiting factor. There are only so many “birth-giving machines… and all we can ask is for them to do their best.”
There has been an outcry in Japan against the health minister though it’s unclear if he’ll resign.
Japan refuses to apologize for crimes against women
Japan admits its army forced women to be sex slaves during World War II but has rejected compensation claims.
Historians believe at least 200,000 young women captured during World War II were forced to serve in Japanese army brothels.
A large number of the victims – who were known as comfort women – were Korean, but they also included Chinese, Philippine and Indonesian women.
The media’s portrayal of young women as sex objects harms girls’ mental and physical health, US experts warn.
Magazines, television, video games and music videos all have a detrimental effect, a task force from the American Psychological Association reported.
Sexualisation can lead to a lack of confidence with their bodies as well as depression and eating disorders.
For more information on kids and sexualization, see Dr. Stryer’s recent blog post.This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
February 8th, 2007 by Dr. Val Jones in News
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I was surprised to find that Kuwait has just edged out the USA in the percent of its population that is reported as “overweight:” 74.2%. Forbes has an interesting visual flag display of the world’s fattest nations.
So what happened to Kuwait? One fairly unhelpful press release suggested that the increase in overweight and obesity was due to changes in diet and exercise habits. Thanks for that insight.
A recent study concluded that the risk of being overweight in Kuwait was positively influenced by income levels and yet the risk of obesity was inversely related to income levels. So, if you’re wealthy you’re more likely to be chubby, but if you’re poor, you’re at risk for obesity? Not sure I understand why that’s so. Maybe everyone has plenty to eat, but only the wealthy can afford gym membership?
Another study correlated increased weight with frequency of dental visits. Does that mean that the more dental work you need the more likely you are to be overweight/obese? I guess Kuwaitis don’t brush their teeth.
What really happened to Kuwait? This happened.This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
February 6th, 2007 by Dr. Val Jones in Opinion
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Last night I was having dinner at Charlie Palmer Steak and entered into a conversation (in Spanish) with one of the wait staff. He was surprised when I ordered in Spanish and we had a friendly conversation about the merits of whole grain bread. He asked me why I spoke Spanish. I answered simply, “porque soy doctora” – because I’m a doctor.
Dr. Richard Reece’s recent blog post tackles the issue of language barriers in the healthcare system. He gives some good advice for cross-cultural communications, reminds us that 25% of US physicians are foreign born, and quotes the inscription on the statue of liberty as the reason why Americans should remember to welcome foreigners. However, he also encourages immigrants to learn English and frowns upon illegal immigration.
As for me, I learned Spanish because I was worried that I’d harm a patient by misunderstanding what they were trying to communicate. Of course we try to have an interpreter at the bedside at all times, but in reality it just doesn’t happen consistently. Learning Spanish was my way of practicing safer medicine.
Now it is frustrating that some patients (at least in NYC) seem to feel as if their doctor is obliged to learn Spanish. They sometimes have an attitude of entitlement that I find hard to swallow. I try to put myself in their shoes, but honestly if I were ill in a foreign country I wouldn’t assume that it was my right to receive care in English.
Still, for me, learning Spanish was a wonderful thing. There is a certain caring that I can communicate, and a certain warmth and appreciation that I feel from my patients as they encourage me – that even though I make mistakes with my grammar, they can still understand my meaning quite well. We laugh a lot at the words I find to describe things – and it generally provides a lighter tone to the interaction. Laughter is good medicine, and if my version of Spanish brings laughter to others – then so much the better!
Do you think US healthcare professionals should make an effort to learn Spanish?
This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
February 5th, 2007 by Dr. Val Jones in News
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Makes being a nurse in the US seem like a cake walk, right?
“The son of Libyan leader Moammar Gadaffi said five Bulgarian nurses and a Palestinian doctor condemned to death by a Libyan court had received unjust verdicts and that they would not be executed, a Bulgarian newspaper reported on Monday.
A Libyan court last month convicted the five Bulgarian nurses and a Palestinian doctor of intentionally infecting more than 400 Libyan children with HIV, despite scientific evidence that the youngsters had the virus before the medical workers arrived in Libya. It sentenced all the medical personnel to death.
‘The original files were manipulated and there were many mistakes, but it was the fault of the police officers and investigators who handled the case at the initial stage.’”
As I was thinking about how these relief workers were “ambushed” I imagined that the parents of the HIV positive children were looking for a scapegoat – there is a lot of stigma associated with HIV, and in a country where mere finger pointing can result in the death penalty… taking care of those infected with the virus can be more deadly than the virus itself.
The article also hinted that if it weren’t for the Bulgarian embassy publicizing the unjust executions, they would have occurred without a second thought.
Let’s hear it for the healthcare workers out there who put their lives in harms way to treat the innocent and helpless. Do you know of other examples?
This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
