March 5th, 2008 by Dr. Val Jones in News
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Patrick Swayze, the popular actor perhaps known best for his role in the 1987 hit movie “Dirty Dancing,” reportedly has pancreas cancer (commonly called pancreatic cancer). Pancreas cancer is among the more deadly forms of cancer. I asked Revolution Health cancer expert Heinz-Josef Lenz, M.D., professor of medicine and professor of preventive medicine in the Division of Medical Oncology at the Keck School of Medicine at the University of Southern California, to explain pancreas cancer.
Dr. Val: Why is pancreas cancer so much more deadly (i.e. less treatable) than many other forms of cancer?
Dr. Lenz: Unfortunately we don’t have very effective drugs for pancreas cancer, which makes it one of the deadliest cancers of all. The median survival is about 8 months with metastatic disease. Even when the tumor is successfully removed there is a very high risk for tumor recurrence. We need more funding to better understand the risk for pancreas cancer and identify and develop more effective therapies.
Dr. Val: Can you describe the typical course of metastatic pancreas cancer?
Dr. Lenz: Unfortunately, the 5 year survival rate for pancreas cancer is only 15 to 20%. The average survival after diagnosis is 12 to 19 months. The best predictor of long term survival is if the tumor is found and removed before it reaches 3 cm in size. Patients with metastatic pancreas cancer are usually treated with a combination chemotherapy consisting of gemcitabine, tarceva, xeloda or oxaliplatin. However the response rates are (despite using aggressive combination therapies) low. Large clinical trials recently did not show any benefit from erbitux or avastin, again demonstrating that pancreas cancer therapy is a difficult clinical challenge.
Dr. Val: Are certain populations at higher risk than others for pancreas cancer?
Dr. Lenz: Age is the most important risk factor for this cancer. It is most common in individuals over age 50 and increases in frequency with age. Black men and women are slightly more likely to get pancreas cancer (though the reasons for this are unclear), and men are slightly more likely than women to get the cancer. Other risk factors are smoking, diabetes, and obesity.
Dr. Val: If you suspect that someone is “high risk” for pancreas cancer, what tests should he/she have?
Dr. Lenz: Patients with a genetic predisposition for breast cancer known as BRCA are also at higher risk for pancreas cancer. There is also a familial form of pancreas cancer. These high risk families are being followed up with specific screening plans. However there is not a reliable test for pancreas cancer. Imaging with CT or MRI can miss pancreas cancer and there is no reliable blood marker. The most common used is CA 19-9, which can be used for monitoring and diagnosis but is not elevated in all patients.
Dr. Val: What if the cancer is caught very early? Does that increase likelihood of survival?
Dr. Lenz: Absolutely. The best chance of survival is when the cancer is limited to the pancreas, and is surgically removed before it reaches a size of 3 centimeters. There are certainly people who have been cured this way, but unfortunately it’s very rare to catch the cancer at such an early stage since it usually has no symptoms until it’s quite advanced.
***
There is a wonderful advocacy group for those whose lives are touched by pancreas cancer: PanCAN. One of PanCAN’s founders, Paula Kim, is a friend of mine and was inspired to create the organization after her dad was diagnosed with pancreas cancer in 1999. At that time there was very little advocacy for this deadly disease. PanCAN helps people with pancreas cancer find help and support.This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
December 12th, 2007 by Dr. Val Jones in True Stories
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A few months ago I wrote about my dear friend who was diagnosed with stage IV colon cancer just after having her first baby. Her optimism and positive focus was inspirational to me, and I marveled at her ability to live life unencumbered by prognosis.
Today I am happy to report that she has completed her 7th round of chemotherapy (with avastin, oxaliplatin, 5FU, and leukovorin) and her liver tumors have already shrunk by two-thirds. She is bothered by neuropathy (burning sensations in her hands and feet – a known side effect of this drug regimen) and has lost the ability to taste food fully, but otherwise she is maintaining her weight and her blood counts are good. She told me that her plan is to complete 12 rounds of chemo and then meet with a liver surgeon to consider surgical removal of the remaining tumors. Miraculously, her doctors believe that she may be a candidate for liver resection and eventual cure.
This couldn’t be any better news and I am so pleased to be able to celebrate my friend’s success. I have learned a great deal myself about the journey, and about how many people are willing to reach out and help those who are struggling. As for my friend, she has greatly benefited from:
1. CarePages – an online gathering place where friends and family can find out the latest news about her progress, and leave well wishes and virtual gifts. CarePages is part of the Revolution Health family.
2. The Colon Cancer Alliance (CCA) – this wonderful non-profit organization linked my friend up with a mentor who has been through a similar treatment regimen and diagnosis and can speak to her about what to expect. The CEO of CCA has even taken time out of his busy schedule to make sure that my friend gets the best support available and has put her in touch with top liver surgeons.
3. Dr. Lenz’s Colon Cancer Blog – Dr. Lenz is a leading medical oncologist and Co-director of both the Colorectal Center and the Gastrointestinal (GI) Oncology Program at USC/Norris Comprehensive Cancer Center in Los Angeles. He also prepares 3 fresh blog posts per week here at Revolution Health, to make sure that cancer patients have access to the latest research and information about colon cancer.
With incredible advances in evidence-based cancer therapies and these terrific online resources, colon cancer patients have a brighter future than ever before. I’m so pleased that my friend is doing well, and I’m grateful for the many people and organizations that have touched her life. Expect another update on her progress in March!This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
September 24th, 2007 by Dr. Val Jones in News
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The oncology community bid farewell to one of its greatest leaders last week, Dr. Marty Abeloff. Marty was a dear colleague of Dr. Avrum Bluming (a guest blogger and friend of Dr. Val & The Voice of Reason) and Av was kind enough to write this obituary to honor him:
On September 14, 2007, Marty Abeloff died.
An intelligent, gracious, caring and supportive human being, he brought all those qualities to his roles as physician, mentor, educator, administrator, and friend.
He was a Phi Beta Kappa graduate of Johns Hopkins and an Alpha Omega Alpha graduate of Johns Hopkins Medical School. He did his house staff/fellowship training at the University of Chicago, the National Cancer Institute, Harvard, the New England Medical Center, and Johns Hopkins. At the time of his death, he was Professor of Medicine and Director of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University. He was a past President of the American Society of Clinical Oncology, past Chairman of the Oncology Drugs Advisory Committee of the Food and Drug Administration, past Chairman of the Board of Scientific Counselors to the National Cancer Institute’s intramural division of clinical sciences, and past Chairman of the Breast Cancer Committee of the Eastern Cooperative Oncology Group. He was the lead Editor of Clinical Oncology, a comprehensive textbook, now in its third printing, Editor of Current Opinion in Oncology, former Associate Editor of the Journal of Clinical Oncology, and founding Editor in Chief of Oncology News International, a wonderfully informative periodical, a position he established and occupied since 1992.
He was held in high esteem by his peers, and beloved by his colleagues, co-workers, patients, students, family members and friends. Patients held on to his phone number long after they finished treatment, and those of us seeking advise in the management of our own patients never hesitated to call upon his help. He was always available and always helpful.
Any individual looking to fashion a life and career distinguished by accomplishment and filled with love could find no finer role model.
Avrum Z. Bluming, MD, MACP
Clinical Professor of Medicine
University of Southern California
This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
September 15th, 2007 by Dr. Val Jones in True Stories
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Physicians see horrible things, tragic injustices caused by unexpected disease and circumstance. We do what we can to remain compassionate – to be emotionally “present” and yet to keep the professional distance required for our survival and success. It takes courage to set a bone, crack a chest, to do painful procedures to save lives – there must be no hesitation when minutes count.
And I suppose that our saving grace is that the majority of the patients we meet in tragic circumstances are not personally known to us. We appreciate their humanity in a general sense, but are not pierced and incapacitated by a family tie or bond of friendship. We are pained by their suffering – but we can cope.
That is, until we’re confronted with a loved one who is thrust into tragedy. Two days ago, a dear friend and former coworker called me to say that she had been diagnosed with colon cancer that had metastasized to her liver. She had just given birth to her first child at age 41. Her only symptom? Post-partum fatigue.
My friend is a health nut and athlete – she has lived the “gold standard” life from a preventive health perspective. I always wanted to be more like her – eating lots of veggies and running regularly. She has been at her target weight all her life, has the occasional glass of wine, and spends much of her free time in community service projects and charity work. She has no history of cancer in her family – they are all hardworking, clean-living types who enjoy long, productive lives.
So when she told me about her advanced disease I almost fell off my chair. How could this happen to her? She is too young! She doesn’t fit the right description… Why didn’t I catch this sooner? Did she ever give me any hint of a warning symptom?
She told me that after having her baby she just felt really tired and was unable to bounce back as quickly as expected. I was worried about post-partum depression, and she eventually decided to see a family physician about her fatigue. He was unclear as to its root cause, and ordered a broad range of general blood tests – including liver function tests. They turned out to be abnormal, and he inquired as to whether my friend might be a drinker. She denied any such tendencies, so he scheduled an ultrasound. The ultrasonographer noted the appearance of metastatic cancer – she had a CT scan and a colonoscopy to confirm the diagnosis of colon cancer. We were both in shock.
And now as my dear friend faces likely surgeries and chemotherapy, I am witness to her journey – the same one that I’ve observed in strangers – but this time I have no professional defenses. I will watch as her body is wracked by the disease’s treatments, I will understand the individual circumstances behind her bravery, I’ll know and feel everything in a personal way that I can’t control.
I am about to join the millions of cancer patients and their families on the other side of the examining room. This time I’m not the doctor, I’m the close friend who rages against a disease that is not fair. And I am ready to fight.This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
June 25th, 2007 by Dr. Val Jones in Expert Interviews, News
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This is the weird correlation of the week: women who suffer with symptoms of morning sickness during their pregnancies may be less likely to develop breast cancer later on in life. A group of epidemiologists in Buffalo recently reported this finding at a scientific meeting (Society for Epidemiologic Research). No one is sure what this means, and I dare not speculate… but perhaps there’s some kind of link between a woman’s hormone levels produced during pregnancy, the nausea they cause, and the hormonal milieu that is the background for breast cancer? Or maybe this study has turned up a false association. Only time – and a lot more research – will tell. Of course, if anyone should speculate on this, it’s the breast cancer oncologists like Dr. Gluck. So I dropped him an email to ask him what he thinks.
Dr. Gluck said that first of all, the association between morning sickness and decreased breast cancer risk is relatively weak. So here’s what the numbers mean: For the average 50 year old woman, the standard risk for developing breast cancer is about 2% (one in
50). According to this study, that same woman (if she had severe morning sickness at some point during pregnancy), is about 1.4% (~30%
less).
Dr. Gluck speculates (and this is quite fascinating) that women with morning sickness are subjected to a hormonal milieu that may result in permanent alterations in their breast tissue. The breast tissue (having been exposed to surges of hormones, insulin, and changing blood pressure and blood sugar levels) might be less vulnerable to the genetic mutations that cause cancer.
We’ve known for a long time that women who have children are at lower risk for breast cancer than women who don’t… now it seems that there might be something about women who are really sick when they’re pregnant and decreased risk of breast cancer as well.This post originally appeared on Dr. Val’s blog at RevolutionHealth.com.
