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Developing New Antibiotics: Thinking Beyond Bacteria Resistance

44s3uqhhro.jpgBacteria may be having a renaissance. Back in the days of the discovery of penicillin, doctors gleefully handed out antibiotics like they were candy and patients were more than happy to munch them down. They were quite effective too, but bacteria rapidly became resistant.

Doctors and scientists worry that we are approaching a time where if we don’t come up with novel antibiotic mechanisms, we will face an epidemic of untreatable bacterial infections. MRSA, methicillin-resistant staphylcoccal auerus, is probably one of the biggest fears.

John Rennie wrote about this issue in the PLoS blog The Gleaming Retort. He describes two strategies scientists are using to try to come up with new weapons in the great antibacterial war. So, naturally one of the first things they turned to was cockroach brains. Read more »

*This blog post was originally published at Medgadget*

New Tool May Help Visually Impaired Learn Braille

Braille BuddyYanko Design blog is profiling the Braille Buddy project that aims to develop a simple-to-use tool to help people who’ve lost eyesight to learn Braille.

Braille Buddy has little retractable bumps that code for different letters, a keyboard, and a voice synthesizer that guides patients through different lessons. The voice will read out letters that a patient has to type back in Braille, and the tactile screen will display letters to read and identify.

Yanko Design: My Best Buddy Braille…

*This blog post was originally published at Medgadget*

Solar-Powered Toothbrush: No Toothpaste Required?

pmyw29jl.jpgResearchers at the University of Saskatchewan have developed a solar-powered toothbrush that doesn’t require toothpaste.

At the base of the brush is a solar panel, which transmits electrons to the top of the toothbrush through a lead wire. These electrons react with acid in the mouth, breaking down plaque without the help of toothpaste. It’s an advancement of a model described 15 years ago using a titanium dioxide rod which released electrons when illuminated.

The researchers are currently recruiting 120 teens to test the brush. The model is named Soladey-J3X and is manufactured by the Shiken company of Japan.

More from Saskatoon StarPhoenix: Solar toothbrush could make toothpaste obsolete…

*This blog post was originally published at Medgadget*

Magnet-Guided Medicine Hits The Spot

Researchers at Lund University in Sweden successfully used magnets to guide clot-dissolving drugs (fibrinolytics) directly to the site of a thrombus stuck within a coronary stent. They did this by attaching the drugs to magnetic nanoparticles and using external magnets to move them to the right spot.

From the press release:

Guiding drug-loaded magnetic particles using a magnet outside the body is not a new idea. However, previous attempts have failed for various reasons: It has only been possible to reach the body’s superficial tissue, and the particles have often obstructed the smallest blood vessels.

The Lund researchers’ attempt has succeeded partly because nanotechnology has made the particles tiny enough to pass through the smallest arteries and partly because the target has been a metallic stent. When the stent is placed in a magnetic field, the magnetic force becomes sufficiently strong to attract the magnetic nanoparticles. For the method to work the patient therefore has to have an implant containing a magnetic metal.

Press release: Medicine reaches the target with the help of magnets…

Abstract in Biomaterials: The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy.

*This blog post was originally published at Medgadget*

A Biomedical Look At Spaceflight

Book review by Dan Buckland

(Dan Buckland is an editor at Medgadget and an MD/PhD student at Harvard Med/MIT whose thesis deals with diagnosing back injury in spaceflight using ultrasound.)

Mary Roach, author of previous entertaining books Bonk (a history of sex research) and Stiff (a history of cadaver research), has turned her considerable talents in translating decades of research into a readable review of human (and animal) spaceflight experimentation.

The title of her new book, Packing for Mars: The Curious Science of Life in the Void, is a bit of a misnomer — only the last chapter is devoted to the medical advances needed for a trip to Mars. However, it is a great layman’s history of the biomedical results of both the American and Russian space programs.

Through my own research and academic career I’ve been peripherally involved with many of the recent studies she mentions in the book, and I know many of the people she interviewed, so I give her credit for taking some fairly complicated concepts and distilling them to relevant anecdotes and asides. Read more »

*This blog post was originally published at Medgadget*

Latest Interviews

IDEA Labs: Medical Students Take The Lead In Healthcare Innovation

It’s no secret that doctors are disappointed with the way that the U.S. healthcare system is evolving. Most feel helpless about improving their work conditions or solving technical problems in patient care. Fortunately one young medical student was undeterred by the mountain of disappointment carried by his senior clinician mentors…

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How To Be A Successful Patient: Young Doctors Offer Some Advice

I am proud to be a part of the American Resident Project an initiative that promotes the writing of medical students residents and new physicians as they explore ideas for transforming American health care delivery. I recently had the opportunity to interview three of the writing fellows about how to…

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Latest Book Reviews

Book Review: Is Empathy Learned By Faking It Till It’s Real?

I m often asked to do book reviews on my blog and I rarely agree to them. This is because it takes me a long time to read a book and then if I don t enjoy it I figure the author would rather me remain silent than publish my…

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The Spirit Of The Place: Samuel Shem’s New Book May Depress You

When I was in medical school I read Samuel Shem s House Of God as a right of passage. At the time I found it to be a cynical yet eerily accurate portrayal of the underbelly of academic medicine. I gained comfort from its gallows humor and it made me…

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Eat To Save Your Life: Another Half-True Diet Book

I am hesitant to review diet books because they are so often a tangled mess of fact and fiction. Teasing out their truth from falsehood is about as exhausting as delousing a long-haired elementary school student. However after being approached by the authors’ PR agency with the promise of a…

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