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The Human Genome Turns 10

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The human genome has been around for a bit more than ten years, but on February 15, 2001, the first complete human genome sequence was published. This was nothing short of a revolution within medicine. Since then, great advancements have been made in our understanding of genetics and its associations with human traits and diseases.

Nature is celebrating this tenth birthday with a special titled “Human Genome at Ten.” In it, multiple papers reflect on what we learned and discovered, what is still unknown, and what we can expect for the near future. Best of all, Nature has packaged the special in a free iPad app for everyone to read, which features interactive graphs, videos, and audio commentaries.

Nature special: The Human Genome at Ten…

iTunes link: Nature Human Genome Special Edition…

*This blog post was originally published at Medgadget*

Kids, Upper Respiratory Viruses, And Ear Infections

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According to a new study published this month, more than 20 percent of young children with colds or other upper respiratory viruses will develop middle ear infections.

This finding isn’t that surprising. Eear symptoms along with a viral upper respiratory infection (URI) are common, including ear fullness and difficulty popping the ear. Although adults tend to be able to keep their ears clear by swallowing, chewing gum, yawning, or ear popping, most kids don’t know what to do when their ears feel full.

Whether in adults or kids, when the ears don’t ventilate or clear properly it can lead to ear problems including fluid buildup and middel ear infection. Why does this occur?

With a viral URI the lining of the nose swells, leading to symptoms of runny nose, nasal congestion, and sometimes nasal obstruction. This swelling doesn’t just occur in the nose, but also in the eustachian tube, which connects the back of the nose to the middle ear. When the ear “pops,” the eustachian tube opens to allow pressure and fluid to drain from the ear into the back of the nose. This is why yawning, swallowing, or noseblowing can cause an ear to pop normally.

When the lining in the eustachian tube swells up, the tube becomes blocked and prevents the ear from popping, leading to symptoms of ear pressure and fullness, fluid buildup, clogging, and often ear infections.

Read more about eustachian tube dysfunction here.

REFERENCE:

Clinical Spectrum of Acute Otitis Media Complicating Upper Respiratory Tract Viral Infection.” Pediatric Infectious Disease Journal. February 2011, volume 30, issue 2, pp 95-99.

*This blog post was originally published at Fauquier ENT Blog*

Narrative Medicine: Healing Through Storytelling

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More in the evolving meme of narrative medicine: Researchers at the University of Massachusetts Medical School (my alma mater) have found that for a select population of individuals, listening to personal narratives helps control blood pressure. While the power of stories is old news, the connection to clinical outcomes is what’s newsworthy here. Read Dr. Pauline Chen’s nice piece in the New York Times. The implications for ongoing work in this area are mind boggling.

The Annals of Internal Medicine study authors sum it up nicely:

Emerging evidence suggests that storytelling, or narrative communication, may offer a unique opportunity to promote evidence-based choices in a culturally appropriate context.  Stories can help listeners make meaning of their lives, and listeners may be influenced if they actively engage in a story, identify themselves with the storyteller, and picture themselves taking part in the action.

This nascent field of narrative medicine caught my eye when I stumbled onto the work of Rita Charon and the concept of the parallel chart. Extrapolation to social media may be the next iteration of this kind of work.

*This blog post was originally published at 33 Charts*

More Physician Temps Needed For Doctor Shortage

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The use of temporary physicians is rising, filling in until permanent physicians can be hired amid the ongoing shortage of doctors nationwide, a locum tenens firm has found. The company estimates between 30,000 and 40,000 physicians worked on a locum tenens basis in 2010.

The survey, by Staff Care, polled hospital and medical group managers about their use of locum tenens. Eighty-five percent said their facilities had used temporary physicians sometime in 2010, up from 72 percent in 2009.

Psychiatrists and other behavioral health specialists were the most sought-after specialty (22 percent of all requests), followed by primary care physicians, defined as family physicians, general internists and pediatricians (20 percent) and internal medicine subspecialists (12 percent). Hospitalists were 9 percent.

According to the survey, the primary reason cited by 63 percent of healthcare facilities was to fill a position until a permanent physician could be found. Forty-six percent of healthcare facilities now use locum tenens physicians to fill in for physicians who have left the area, compared to 22 percent in 2009. Fourteen percent use locum tenens doctors to either help meet rising patient demand for medical services or to fill in during peak times, such as flu season. Fifty-three percent use locum tenens physicians to fill in for physicians who are on vacation, ill or for other absences.

Most locum tenens physicians plan to stick with temporary practice in the short-term, the company noted. Sixty percent said they plan to practice on a locum tenens basis for more than three years, 28 percent for one to three years and 12 percent for less than a year.

Freedom trumps pay, the company noted, as 82 percent cited flexibility as a benefit, compared to 16 percent who identified pay as a benefit. Other reasons cited for working as a locum tenens include absence of medical politics (48 percent), travel (44 percent), professional development (21 percent) and searching for permanent practice (20 percent).

The locum tenens option is important to maintaining physician supply, the company concluded, because during a time of physician shortages it allows doctors who might be considering full retirement to remain active in medicine.

*This blog post was originally published at ACP Internist*

Diet Soda And Your Risk For Heart Attack Or Stroke

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It tastes sweet. It’s pleasurably fizzy. And free of calories. What’s more, the FDA says NutraSweet (aspartame) is safe. So what’s not to like about diet soft drinks?

A bunch. The ongoing debate about the healthiness of diet soft drinks reminds me of the old adage, “If something sounds to be true, it probably is.”

Artificially-sweetened “diet” drinks get touted as healthy alternatives to sugary drinks because they contain no calories or carbohydrates. On paper it seems plausible to think they are inert, no more dangerous than water. The Coca-Cola Company sublimely strengthens this assertion by putting a big red heart on Diet Coke cans.

But diet-cola news (Los Angeles Times) presented at the International Stroke Conference 2011 suggests otherwise. This widely-publicized observational study of 2,500 older patients (average age=69) from New York showed that drinking diet soda on a daily basis increased the risk of having a heart attack or stroke by 61 percent. The abstract — not a peer-reviewed study — stated that this association persisted after controlling for other pertinent variables.

Sure, this is only a look back at 559 patients who had a vascular event. The study asserts only an association, not that diet colas cause heart attacks and strokes. That’s a big difference.

That said, however, I don’t view these results as trivial either. This trial builds on the results of prior studies of diet drinks which strongly suggest that despite their lack of calories, diet drinks don’t prevent obesity. Read more »

*This blog post was originally published at Dr John M*

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