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Treatment-Resistant Depression: New Insights

Only one-third of people with major depression achieve remission after trying one antidepressant. When the first medication doesn’t adequately relieve symptoms, next step options include taking a new drug along with the first, or switching to another drug. With time and persistence, nearly seven in 10 adults with major depression eventually find a treatment that works.

Of course, that also means that the remaining one-third of people with major depression cannot achieve remission even after trying multiple options. Experts are hunting for ways to understand the cause of persistent symptoms. In recent years, one theory in particular has gained traction: that many people with hard-to-treat major depression actually suffer from bipolar disorder. However, a paper published online this week in the Archives of General Psychiatry suggests otherwise — and the findings provide new insights into the nature of treatment-resistant depression. Read more »

*This blog post was originally published at Harvard Health Blog*

New Recommendations For Vitamin D

Vitamin D has been talked about as the vitamin — the one that might help fend off everything from cancer to heart disease to autoimmune disorders, if only we were to get enough of it.

“Whoa!” is the message from a committee of experts assembled by the Institute of Medicine (IOM) to update recommendations for vitamin D (and for calcium).

The IOM committee’s report, released this morning, says evidence for many of  the health claims for vitamin D is “inconsistent and/or conflicting or did not demonstrate causality.” The exception is the vitamin’s well-documented (and noncontroversial) benefits on bone growth and maintenance.

The IOM panel’s report also says most North Americans (Canadians as well as Americans) have more than enough vitamin D in their blood to achieve the desired effect on bone. The committee said a blood level of 20 nanograms per milliliter (ng/mL) is sufficient for most people.

The panel set 600 International Units (IU) as the recommended daily intake for children and for adults ages 19 to 70. People ages 71 and older are supposed to get an additional 200 IU, or 800 IU a day.

That’s a fairly sizable increase over the previous recommendations of 200 IU per day through age 50, 400 IU for people ages 51 to 70, and 600 IU for people ages 71 and older. Read more »

*This blog post was originally published at Harvard Health Blog*

Young Doctors Who Lie

This is something: A study published in the July 20, 2010 Annals of Internal Medicine finds that 5 percent of residency applications contain plagiarized content. The study from Boston’s Brigham & Woman’s Hospital is based on the personal statements of nearly 5,000 residency applicants that were matched against a database of published content.

The authors comment that the study is limited, among other things, by the fact that it was done in just one institution. It makes me wonder if the number is artificially high or potentially too low.

So why would medical students lie? Read more »

*This blog post was originally published at 33 Charts*

The Global Burden Of Diseases: Who’s Healthier On The Planet?

survey_button_square.gifMy friend and colleague Bill Heisel, one of our news reviewers, also works at the Institute for Health Metrics and Evaluation (IHME) at the University of Washington. He wrote to me that this group:

“… has launched a major global health survey to measure the impact of more than 300 diseases or injuries and more than 40 risk factors. This is the most ambitious global health measurement project in two decades. And when people answer the survey, they will be providing information that will directly shape the final outcome of the research because ‘disease burden’ is partly objective but partly subjective.”

And his pitch to anyone to take the 15-minute, anonymous, online survey is this:

“With unprecedented money and attention pouring into global health efforts, the need for accurate data is urgent. By taking part in the survey, you will contribute to the scientific understanding of global health problems and ultimately enable policymakers to make better decisions.”

Click HERE to begin the survey. Thanks for the news, Bill. And thanks to anyone who takes the time to complete the survey. You may help this team reach its goal of 50,000 people around the globe filling out the survey.

The research is part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 led by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington, in collaboration with Harvard University, Johns Hopkins University, the University of Queensland, and the World Health Organization (WHO).

And you can follow the project on Twitter.

*This blog post was originally published at Gary Schwitzer's HealthNewsReview Blog*

Why Tobacco Should Be Childproof

A number of colleagues recently mentioned to me that they’ve heard that new smokeless tobacco products are very dangerous because they cause a lot of poisonings to children.

When I checked the Internet, sure enough — there were plenty of news headlines along the lines of “Tobacco mints tied to poisoning in kids” and “Tobacco candy poisoning kids, study shows.” I thought this looked interesting, particularly as I was unaware of any “tobacco candy.” Read more »

This post, Why Tobacco Should Be Childproof, was originally published on Healthine.com by Jonathan Foulds, Ph.D..

Latest Interviews

IDEA Labs: Medical Students Take The Lead In Healthcare Innovation

It’s no secret that doctors are disappointed with the way that the U.S. healthcare system is evolving. Most feel helpless about improving their work conditions or solving technical problems in patient care. Fortunately one young medical student was undeterred by the mountain of disappointment carried by his senior clinician mentors…

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How To Be A Successful Patient: Young Doctors Offer Some Advice

I am proud to be a part of the American Resident Project an initiative that promotes the writing of medical students residents and new physicians as they explore ideas for transforming American health care delivery. I recently had the opportunity to interview three of the writing fellows about how to…

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Latest Book Reviews

Book Review: Is Empathy Learned By Faking It Till It’s Real?

I m often asked to do book reviews on my blog and I rarely agree to them. This is because it takes me a long time to read a book and then if I don t enjoy it I figure the author would rather me remain silent than publish my…

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The Spirit Of The Place: Samuel Shem’s New Book May Depress You

When I was in medical school I read Samuel Shem s House Of God as a right of passage. At the time I found it to be a cynical yet eerily accurate portrayal of the underbelly of academic medicine. I gained comfort from its gallows humor and it made me…

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Eat To Save Your Life: Another Half-True Diet Book

I am hesitant to review diet books because they are so often a tangled mess of fact and fiction. Teasing out their truth from falsehood is about as exhausting as delousing a long-haired elementary school student. However after being approached by the authors’ PR agency with the promise of a…

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