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Could Glowing Cats Be The Key To Finding A Cure For HIV?

Photo courtesy of the Mayo Clinic Scientists have added a new species to the menagerie of animals that glow, after introducing jellyfish genes into cats that can now glow green.

Scientists report that they transferred genes from monkeys (and jellyfish) into cats in order to study feline immunodeficiency virus (FIV), the cat equivalent of HIV. In cats and in people, immunodeficiency viruses deplete infection-fighting T-cells. Key proteins called restriction factors that would normally defend against the viruses are ineffective. The research appears in the September issue of Nature Methods.

To research potential treatments, physicians, virologists, veterinarians and gene therapy researchers from the Mayo Clinic and in Japan sought to mimic the way evolution would generate protective protein versions, according to a Mayo Clinic press release. They inserted monkey versions of a gene into the cat genome using gamete-targeted lentiviral transgenesis. This is done by inserting genes into feline eggs before sperm fertilization.

The monkey restriction factor, TRIMCyp, blocks FIV by attacking and disabling the virus as it tries to invade a cell. In the lab, the transgenic cat lymphocytes resisted FIV replication. The scientists said that they can now test the potential of various restriction factors for Read more »

*This blog post was originally published at ACP Internist*

Penalties Will Not Promote Participation In ACOs

As we get closer to January 2012, the originally scheduled implementation date for Accountable Care Organizations (ACOs), the time has come to reexamine the showpiece of President Obama’s Patient Protection and Affordable Care Act (PPACA) of 2010.

The final rules for ACO’s are now scheduled for release on January 2012. The implementation was originally scheduled for January 2012. As the original rules are being studied and interpreted the program for ACOs implementation became more confusing. Dr. Don Berwick (CMS Director) has refused to discuss the final rules until they have been published in the Federal Register.

“The ACO program is based on the hubristic assumption that the federal government can design the best organizational structure for the delivery of care, foster its development, and control its operation for the entire country.

The federal government has big-footed health system reform. Although there is no one right way to organize care, the federal government (Dr. Don Berwick and President Obama) thinks it has found one—and exerts top-down, bureaucratic control through PPACA to implement it.”

ACOs are supposed to be organizations that improve coordinated care. If an ACO decreases the cost of care Read more »

*This blog post was originally published at Repairing the Healthcare System*

After One Year, The Mayo Clinic Center For Social Media Is Still Going Strong

I’ve always been a great fan of what Mayo Clinic has been doing on social media. Then after Mayo Clinic Center for Social Media was launched, I became a member of the international external advisory board which I’m very proud of. I reported when they launched a patient community and also discussed how well they did this. Now the Center is 1 year old and still performs perfectly. An excerpt form their previous entry:

Here’s a sneak peek of a few topics that were discussed during Mayo’s retreat: Read more »

*This blog post was originally published at ScienceRoll*

Patient Empowerment Has The Potential To Be Problematic

Let me say first that I am a practicing primary care doctor who is very much focused on patient centered care.  Though I cannot go back to being a patient who is unaware about what a doctor does, the terminology she uses, or what the importance of certain test results are, I can empathize with the overwhelming amounts of information, challenges, and stressors patients and families can have in navigating the healthcare system to get the right care.  This is the reason I wrote my book.

However, over the past few months I’ve noticed a particularly disturbing trend.  Patients are not consulting doctors for advice, but rather demanding testing for diagnoses which are not even remote possibilities.  A little knowledge can be dangerous particularly in the context of little to no clinical experience.  Where many patients are today are where medical students are at the end of their second year – lots of book knowledge but little to no real world experience.

More patients are becoming the day traders of the dot.com boom.  Everyone has Read more »

*This blog post was originally published at Saving Money and Surviving the Healthcare Crisis*

The Importance Of Social Media In The Medical Field

Recently,  I had the pleasure of being surrounded by brilliant health care thought leaders.  First, I delivered a social media presentation at the Eyeforpharma conference.  Secondly, I sat in the audience at the Social Communications and Health Care 2011 conference to listen to others present on social media, and participate in a round-table discussion on social media.

It’s clear from the personal discussion that followed with folks from the pharma industry, medical device companies, and hospitals, that they understand the need for social media (or social networking), but they are cautious to dive in.

A few concerns I’ve heard:  “social media can be paralyzing,” “senior leadership in the pharma industry is looking for the FDA to make decisions because it’s such a highly regulated industry,” and “it’s still so new, what’s the ROI?”  Concerns are real; however there will always be concerns and questions.  Sometimes, the best approach is to just dive right in.

The brilliant reason to dive deep into the social media health space is Read more »

*This blog post was originally published at Health in 30*

Latest Interviews

IDEA Labs: Medical Students Take The Lead In Healthcare Innovation

It’s no secret that doctors are disappointed with the way that the U.S. healthcare system is evolving. Most feel helpless about improving their work conditions or solving technical problems in patient care. Fortunately one young medical student was undeterred by the mountain of disappointment carried by his senior clinician mentors…

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How To Be A Successful Patient: Young Doctors Offer Some Advice

I am proud to be a part of the American Resident Project an initiative that promotes the writing of medical students residents and new physicians as they explore ideas for transforming American health care delivery. I recently had the opportunity to interview three of the writing fellows about how to…

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Latest Book Reviews

Book Review: Is Empathy Learned By Faking It Till It’s Real?

I m often asked to do book reviews on my blog and I rarely agree to them. This is because it takes me a long time to read a book and then if I don t enjoy it I figure the author would rather me remain silent than publish my…

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The Spirit Of The Place: Samuel Shem’s New Book May Depress You

When I was in medical school I read Samuel Shem s House Of God as a right of passage. At the time I found it to be a cynical yet eerily accurate portrayal of the underbelly of academic medicine. I gained comfort from its gallows humor and it made me…

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Eat To Save Your Life: Another Half-True Diet Book

I am hesitant to review diet books because they are so often a tangled mess of fact and fiction. Teasing out their truth from falsehood is about as exhausting as delousing a long-haired elementary school student. However after being approached by the authors’ PR agency with the promise of a…

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