December 8th, 2011 by John Di Saia, M.D. in Research
Tags: Dermatology, Plastic Surgery, Skin Cancer, Sunscreen, Vitamin A
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“According to that study, nearly half of the 500 most popular sunscreens may actually increase the speed at which malignant cells develop and spread skin cancer such as melanoma.
Why? Because they contain Vitamin A, an ingredient that was added to sunscreen formulations because it’s an antioxidant that slows skin aging.
This isn’t necessarily new information….as some studies suggest “that vitamin A might have some phototoxicity.”
Source: health.msn.com/health-topics/skin-and-hair/articlepage.aspx?cp-documentid=100260739
Take it easy folks. One study on the effects of Vitamin A on skin cancers in animals does not invalidate sunscreen use. We don’t really need Vitamin A in sunscreens though. We need good blockers of UVA and UVB at an SPF of at least 30.
*This blog post was originally published at Truth in Cosmetic Surgery*
December 7th, 2011 by DrRich in Health Policy, News, Opinion, Research
Tags: Cardiac Events, Healthcare Policy, Optimal Levels, Salt Intake, Sodium Restriction
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This past summer, DrRich wrote a post on the utter arrogance of the public health experts who are urging the FDA – and international bodies of busybodies – to mandate a policy of strict sodium restriction across the globe.
DrRich attempted to show how such a broad-based salt restriction at this juncture is ill-advised for three reasons. First, the conclusion that a population-wide salt restriction would actually do any good is not based on any actual prospective studies, but on a contrived extrapolation of observational data. Second, there is some evidence that a salt restriction would be harmful to at least a substantial minority of people, even if the overall effect on the population turns out to be positive. And third, there is good reason to believe that the degree of sodium restriction which is being recommended by the public health experts is below the level which is dictated by human physiology.
Perhaps salt restriction for the entire population will turn out to be a good idea. But perhaps not. So in his previous post, DrRich was advocating a prospective, randomized controlled trial to test this proposition before just going ahead and inflicting it upon hundreds of millions of Americans.
And now, as it happens, in recent weeks new studies have been published which question the safety of salt restriction for the whole population. In fact, five studies have been published just this year suggesting that salt restriction might be unsafe.
The latest, published this week in the Journal of the American Medical Association, suggests that when you compare cardiovascular events (such as heart attack and stroke) to sodium intake, the incidence of those events follows a “J” curve. That is, cardiovascular events are lowest at an “optimal” level of sodium intake. But if sodium intake goes above that optimal level – or if it goes below it – the incidence of cardiovascular events increases. Read more »
*This blog post was originally published at The Covert Rationing Blog*
December 7th, 2011 by RyanDuBosar in News, Research
Tags: End Of Life, Heart Failure, Longevity, Palliative Care, Patient Communication, Priorities, Quality of Life
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Don’t assume elderly heart failure patients are assumed to prefer improved quality of life over longevity, study authors noted. The majority of them prefer longevity over quality of life, half expressed a desire for resuscitation if needed, and it was difficult to predict individual preferences.
Researchers looked at patients’ willingness to trade survival time for quality-of-life and the preferences for among 622 heart failure patients aged 60 or older participating in the Trial of Intensified vs. Standard Medical Therapy in Elderly Patients with Congestive Heart Failure.
End-of-life preferences were assessed by using a time trade-off tool and one question concerning CPR preference. To assess time trade-off, patients were asked whether they preferred living 2 years in their current state of health or living 1 year in excellent health. If 1 year in excellent health was chosen, the patients were asked whether they would prefer 2 years in their current state of health or 6 months in perfect health. If 2 years in the current state were chosen, then they were asked whether they would prefer 2 years in their current state of health or 18 months in perfect health. The series continued until the choices were the same. This time point subtracted from 24 months derived the number of months of survival time that the patient would be willing to trade.
End-of-life preferences were assessed at baseline, and at 12 and 18 months. Read more »
*This blog post was originally published at ACP Hospitalist*
December 6th, 2011 by Medgadget in Research
Tags: Hypothalamus, Leptin, Neurology, Neurosurgery, Obesity Treatment, Rats, Transplant
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Obesity is the most significant chronic healthcare crisis facing the United States, as well as other countries. Already 1 out of every 3 adults, and 1 out of every 6 children or adolescents, in the U.S. is obese! Leptin is a hormone that has received considerable attention since its discovery in 1994 for its role in regulating metabolism (like a thermostat, or adipostat) and implications for obesity. High leptin levels are associated with feeling satiated and an active metabolism. Though many overweight people have high levels of circulating leptin, it’s been found that their hypothalamic neurons do not receive the signal – a phenomenon known as “leptin resistance.” An animal model that mirrors this is db/db mice, which lack leptin receptors on the surface of they hypothalamic neurons and are therefore morbidly obese (see image).
Reporting in Science this past week, researchers at Harvard Medical School transplanted neurons with the leptin receptor into the hypothalami of db/db mice and as a result were able to partially restore leptin sensitivity and ameliorate their obesity. Two to three months after transplanting 15,000 (a relatively small number) fluorescently-tagged, leptin sensitive neurons into the db/db mice hypothalami, they observed statistically significant drops in blood sugar levels, leptin concentration, and fat mass. In terms of the mechanism and implications, the team concludes: Read more »
December 6th, 2011 by MellanieTrueHills in Research
Tags: Atrial Fibrillation, Catheter Ablation, Dr. John Mandrola, Gender Differences, Study, Success Rates, Treatment, Women
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At the American Heart Association Scientific Sessions 2011, Dr. John Mandrola presented a poster on gender-specific results of atrial fibrillation ablation in a private practice setting. In this video interview with him about the poster, he mentioned that in his experience women appear to be more challenging to treat with atrial fibrillation ablation and do not appear to fare as well as men from it. In addition, it appeared that women were referred more often for AV node ablations than men.
*This blog post was originally published at Atrial Fibrillation Blog*
